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General: Colchicine should be administered with great caution to aged and debilitated patients, especially those with renal, hepatic, gastrointestinal, or heart disease. Reduction in dosage is indicated if weakness, anorexia, nausea, vomiting, or diarrhea occurs.
Drug Interactions: Colchicine has been shown to induce reversible malabsorption of vitamin B12, apparently by altering the function of ileal mucosa. The possibility that colchicine may increase response to central-nervous-system depressants and to sympathomimetic agents is suggested by the results of experiments on animals.
Use in Pregnancy: Pregnancy Category D: See Warnings.
Use in Lactation: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when colchicine is administered to a nursing woman.
Use in Children: Safety and effectiveness in children have not been established.
